A genome-wide scan points to a susceptibility locus for bipolar disorder on chromosome 12
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چکیده
منابع مشابه
A genome survey indicates a possible susceptibility locus for bipolar disorder on chromosome 22.
Bipolar disorder or manic depressive illness is a major psychiatric disorder that is characterized by fluctuation between two abnormal mood states. Mania is accompanied by symptoms of euphoria, irritability, or excitation, whereas depression is associated with low mood and decreased motivation and energy. The etiology is currently unknown; however, numerous family, twin, and adoption studies ha...
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Substantial evidence supports the familial aggregation of exceptional longevity. The existence of rare families demonstrating clustering for this phenotype suggests that a genetic etiology may be an important component. Previous attempts at localizing loci predisposing for exceptional longevity have been limited to association studies of candidate gene polymorphisms. In this study, a genome-wid...
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High myopia often appears as a familial disease. It is usually defined as a refraction error equal to or below −6 diopters (D) in each eye. Highly myopic patients represent 27-33% of the myopic population. The prevalence of the disease in the general population varies according to the country, from 2.1% in the USA, to 3.2% in France, and up to 9.6% in Spain. High myopia is also termed “patholog...
متن کاملGenome-wide scan for schizophrenia in the Finnish population: evidence for a locus on chromosome 7q22.
We report the results of a four-stage genome-wide scan in a schizophrenia study sample consisting of 134 affected sib-pairs collected in Finland. In stage I we genotyped 370 markers from the Weber 6 screening set ( N = 52 affected sib-pairs); in stage II we followed up 40 markers by typing first-degree relatives of the sib-pairs; in stage III we genotyped 15 markers in 134 families; and in stag...
متن کاملGenome-wide linkage scan of a large family with IgA nephropathy localizes a novel susceptibility locus to chromosome 2q36.
IgA nephropathy (IgAN) is the most common glomerulonephritis worldwide and an important cause of ESRD. Familial clustering of cases suggests genetic predisposition to this disease. Two recent genome-wide studies in IgAN have identified a major susceptibility locus on chromosome 6q22 (IGAN1) and two additional loci with suggestive linkage signals on chromosomes 4q26-31 and 17q12-22. A large four...
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ژورنال
عنوان ژورنال: Molecular Psychiatry
سال: 2004
ISSN: 1359-4184,1476-5578
DOI: 10.1038/sj.mp.4001601